Step 10 – Alternative to Mesalamine Enemas

Step 10 – Alternative to Mesalamine Enemas

– by giving you healthy alternatives to the mesalamine enemas/suppositories, which by their mere biological make-up work synergistically within your small intestine, and can begin to repair the damage your disease produced.

Why and How?

A) Butyrate

Butyrate (also known as butyric acid) is a short-chain fatty acid produced when intestinal fiber is metabolized by bacteria. Butyrate ameliorates inflammation in ulcerative colitis and Crohn’s disease, but the mechanism is not known. One mechanism by which butyrate may function is to inhibit the activation of a proinflammatory cell–signaling component called nuclear factor kappa B (NF-kappa B). This inhibition makes cells less responsive to proinflammatory cytokines (Segain JP et al 2000). Butyrate is often administered as an enema twice daily. The turmeric extract known as curcumin also inhibits NF-kappa B and can be taken orally.

Butyrate Enemas Studies

Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.

Gut. 1996 April; 38(4): 568–573.  PMCID: PMC1383116

J D Butzner, R Parmar, C J Bell, and V Dalal

Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada.

–The short chain fatty acid (SCFA) butyrate provides energy for colonocytes, stimulates colonic fluid and electrolyte absorption and is recognised as an effective treatment for multiple types of colitis. AIM–To examine the impact of butyrate enema therapy on the clinical course, severity of inflammation, and SCFA stimulated Na+ absorption in a chronic experimental colitis. METHODS–Distal colitis was induced in rats with a trinitrobenzenesulphonic acid (TNBS) enema. Five days after induction, rats were divided into groups to receive: no treatment, saline enemas, or 100 mM Na-butyrate enemas daily. On day 24, colonic damage score and tissue myeloperoxidase (MPO) activity were evaluated. Colon was mounted in Ussing chambers and Na+ transport and electrical activities were measured during a basal period and after stimulation with 25 mM butyrate.

RESULTS–In the untreated and the saline enema treated TNBS groups, diarrhoea and extensive colonic damage were seen, associated with increased tissue MPO activities and absent butyrate stimulated Na+ absorption. In contrast, in the butyrate enema treated TNBS group, diarrhoea ceased, colonic damage score improved, and tissue MPO activity as well as butyrate stimulated Na+ absorption recovered to control values.

CONCLUSIONButyrate enema therapy stimulated colonic repair, as evidenced by clinical recovery, decreased inflammation, and restoration of SCFA stimulated electrolyte absorption.

Step 10 – Alternative to Mesalamine Enemas

Where do I buy the Butyral Enemas?

I asked my doctor to prescribe it for me. In the initial stages of my Ulcerative Colitis, I used 2 Butyral enemas per day for 3 weeks.

B) Another Alternative to the 5ASA or mesalamine enemas is:


Suppositories #2  by Wise Woman Herbals (12 count)

Suppositories #2 12 count by Wise Woman Herbals

Suppositories #2

  • Relieves irritation, protects tissue, promotes healthy tissue & mucosa.
  • Homeopathic Formula.

Suggested use: Take as directed by a qualified healthcare professional.


  • Althaea officinalis (marshmallow),
  • Hamamelis virginiana (witch hazel),
  • Ruscus aculeatus (butcher’s broom),
  • Collinsonia canadensis (stoneroot),
  • allantoin,
  • vitamin A, and vitamin E in a cocoa butter base.
12 count

Average Rating on 1 Reviews

Step 10 – Alternative to Mesalamine Enemas

(5 stars in 1 rating(s))


Wise Woman Suppositories #2 3/12/2010

“Recommended by my doctor for a specific ailment. This product is particularly pleasant to use and is all natural. Wise Women Herbals sets a very high standard in all natural remedies and supplements. Their products are not cheap, as a result.” Reviewed by Hugo Valdez from Santa Fe, NM.


Although there are no studies I can provide to document how well this product works (none have been done), I have heard many anecdotal success stories of these suppositories being more effective than Canasa suppositories.


The other great thing about these are no prescription is needed, and they have NO SIDE EFFECTS.

Click here to find out more information on these suppositories

That together with all the other steps I outlined  in the Alternative Protocol has helped me so that I am now symptom free.  Again, I can’t stress enough that this in an integrative approach and unfortunately, there is no one “magic pill” that’s going to solve your Ulcerative Colitis, IBS, IBD, or Crohn’s Disease.


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